Lemmy is definitely different from how mailing lists work in practice - much faster to get updates on, more ergonomic, etc., but in theory - could SMTP, IMAP, and a bit of ingenuity be used to turn a mailing list into a Lemmy-like interface for comments, links, etc?
I just had the idea of making a mailing list-based ActivityPub host lol, but it would probably be much slower than Lemmy in just about every way because of protocol overhead.
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I mean, as an aside, if someone comes up with a crazy shitposting mailing list, let me know