Any vpn solution that uses a TCP/IP shim in full tunnel mode will ignore option 121 or any other routing options (static routes, etc). Most corporate VPNs like Global Protect/Cisco Any Connect, Appgate, etc will enforce full-tunnel. Any user who is using a VPN for privacy reasons should also use a full tunnel as well especially when connecting to an untrusted networks.
Any vpn solution that uses a TCP/IP shim in full tunnel mode will ignore option 121 or any other routing options (static routes, etc). Most corporate VPNs like Global Protect/Cisco Any Connect, Appgate, etc will enforce full-tunnel. Any user who is using a VPN for privacy reasons should also use a full tunnel as well especially when connecting to an untrusted networks.