I set up calibre-web on my home server but didn’t use it for very long. I’ve got my books separated into fiction, nonfiction and technical libraries and calibre-web could only handle one library database. I would have had to run multiple instances to get the different libraries served. I also still had a need to use calibre on my desktop so it was necessary to reimport the database from my desktop into calibre-web to keep things in sync. If you’re going to manage everything in the web interface it might work for you. It was just kind of unnecessary for my needs.