It used to be mostly smoking; now it’s mostly eating animal products and processed food, and poor sleeping. The advice given for decades is still valid: only whole-plant food and water, lots of exercise, and proper sleep.
Possible reasons listed in article:
- obesity,
- metabolic syndrome (abdominal obesity, high blood pressure, high blood sugar, high serum triglycerides, and low serum high-density lipoprotein),
- added sugar,
- processed food,
- ultra-processed foods,
- consistently high blood glucose,
- insulin resistance,
- change in sleep patterns (children sleeping less, shift work and artificial light),
- microplastics,
- antibiotics.
If you think your grandparents would prefer the Windows 8 or macOS type UI, then GNOME is the way.
I think Xfce or MATE is vastly better tho.