I’ve been running Silverblue for 2 years. Apart from the hiccups mostly at the beginning of that time, things have been running very smooth and I haven’t had any issues worth mentioning. Things that have been and still are hassles are e.g. missing media codecs (ffmpeg and friends) and kernel configs & modules (e.g. drivers such as nvidia). I had to learn a few new tricks with flatpak but my major use case - Steam - runs as flawless as it does on other platforms.
I had issues with the “enhanced” GOG version. Starting it requires an ancient openssl library which is no longer available on modern platforms. If you launch the game via terminal or check the logs Lutris provides you might see an error message similar to “openssl.1.0.0…so not found”. If thats the case I can dig up more specific instructions to circumvent the issue which got me into the game. Just to clarify, installation worked, it was just the game necer started or rather instantly crashed.