

See: https://www.omnicalculator.com/other/hyperfocal-distance
https://en.wikipedia.org/wiki/Hyperfocal_distance
But TL;DR: for distant landscapes on a wide field of view lens, you can shoot at F5.6 and everything is in focus. I even do this at F1.4 on my lowly aps-c camera.
Put more concretely, the hyperfocal distance for a 35mm f5.6 lens on a medium format camera is 5 meters. Everything in the distance can be in focus.
For portraits, you want background blur anyway.
And if you’re doing anything else on a medium format camera, you’re kind of insane, heh.










As a real life example, the Canon 600mm F11 telephoto lens should be awful, on, say, a 32MP crop sensor R7. That’s insane pixel density somewhere in the ballpark of this Fuji.
…But look at real life shots of that exact combo, and they’re sharp as hell. Sharper than a Sigma at F6.3.
The diffraction limit is something to watch out for, but in reality, stuff like the lens imperfections, motion blur, atmospheric distortion and such are going to get you first. You don’t need to shoot at F4 on this thing to make use of the resolution, even if that is the ideal scenario.