Awesome write up. I appreciate the transparency and the knowledge transfer for others trying to keep their Lemmy instances up under load.
I too use B2 for a restic target in my home network. I’m not delivering any content, but I’m assuming you are aware of the B2 integration with CDN’s that at least don’t incur B2 egress charges? https://www.backblaze.com/b2/solutions/content-delivery.html
I’d assume there are CDN bandwidth charges involved. I have no idea how those compare to the VPS charges. I’m also certain the setup isn’t simple.
I’m looking forward to similar posts and can’t express how much I appreciate the transparency.
Metformin has a strange history. There was evidence in animal studies as early as the 1920’s that it could lower blood sugar, but wasn’t approved as a diabetic treatment until the 50’s. The US didn’t approve it until the 90’s.
It’s still not clear how it works. There continue to be articles like this hinting that it could have other beneficial effects, including a lower incidence of cancer and longer life, which again no one can explain how. All the research pointing at other effects besides blood sugar are observational and longitudinal in nature.
Lest someone think it’s a wonder drug, all these effects are relatively subtle, and side effects for many include things like explosive diarrhea.