I imagine it’s classified, but NASA being NASA, you know a full risk assessment along these lines exists, probably with dutiful updates as it’s still an active program. It would be fascinating read especially with the updates, with how much the world has changed while the probe remained the same.

I don’t get the panic. It worked great for 50% of Venture brothers.

Not going to lie, despite loving the stories about the monkey king, I skipped it entirely because of the notes they sent to content creators. Which would also be why I skip movies and games that take the US’ DoD money. I’m glad it got passed over.

ooooh this is it! If you wanted to optimize evil add photosynthesis and nitrogen fixing and you’ve got it.

Hell, I’d bet you could work on the chloroplasts in isolation of the rest of the organism to parallel path the research and optimize.

I’ve been out of synthetic bio for damn near two decades now, and an undergrad when was I even in it, but I’m not so sure. PCR didn’t come around until 85. I had professors that used to do every cycle manually. Human genome project wrapped in 03(?). You can order custom oligos for like $0.13USD a base pair mail order now. You type it in on a webform, a machine creates a custom molecule for you, and if you want to pay a little extra you can have it over-night. I suppose it depends what you call “near future”, and synthetic biology has always had moving goal posts when it came to “functional liposome” and “synthetic life”, but I don’t know… shit can move fast sometimes.

you bet! I just remember that because we were learning about glucose is taken up (it’s an active process swapping sodium and potassium). Another fun bonus for you: thats what they figured out at university of florida (or at least implemented). Someone had the bright idea that if you gave athletes a beverage with not only glucose but the specific K+/Na+ they needed to run the enzymes that took up the glucose, they might perform better.

So the football team, the Gators, got a special concoction of “Gator-aide” at their games. It smelled kinda like sweat, wasn’t sweet (glucose isn’t actually that sweet), so the formula was eventually tweaked, the branding changed to “gatorade”, but the university still RAKES in the money for that license.

edit: Just to add another cool layer. The money to date has nothing to do with the innovation, that patent would have expired (which is fantastic because that concoction is basically how you treat all sorts of things like cholera where the body dies of dehydration despite having clean water, the UN, FEMA, etc basically hands out off-brand gatorade mix). The reason U of florida still gets the money isn’t formula, it’s the brand. Pepsi pays them for that “gator-aide” name. It’s rare IP perfect win; hydration mix for all, and if you there’s a business to be made selling it under a specific name so be it, doesn’t matter much to the person whos life is saved because of “generic hydration mix”.

Ok. THANK YOU. I also have to say my biggest issue with the newer one (I forget which) is when the parks going to hell, and the park director just decides to go off into the jungle. Like outside of just design of the park, there is NO way you don’t have rigid protocols in-place. Like you read about half the crap Disney does/can do at their parks… there’s no way the head of the park just goes “oh you guys got this, I’ll be back at some point, just do your best”.

Like if ONLY for the reason it would be a known PR disaster for something that in universe already had PR disasters… that shit would have been drilled in since day -1000. It’s my biggest issue with the writing because it’s not even sci-fi.

/end rant.

Sorry about your grandfather. There’s probably more than one mechanism for alzeimers (not an expert), but amaloyid plaque formation, which is definitely A way to develop alzheimer’s, is indeed a prion like event. I’m not sure if “prion” has some hyper-precise definition but the ideas similar: you get one amalyoid protein that misfolds, and acts as a nucleation site misfolding and agglomerating others.

“mirror sugar”. Just dropping some trivia. The first “no calorie” sweetners were actually mirror sugar. They’d activate tastebuds but couldn’t be adsorbed in the gut. Only problem was people crapped their brains out because the osmotic balance went to hell.

edit: I think technically the first zero calorie sugar would have been literal lead (as in Pb) back in the ancient roman days, but I’m not really counting that.

Jumping in down here. I agree with you entirely that racemic mixes are a very different ball than mirror organisms; it’s been a known thing for a long time, and while I’m not positive, I’d be very surprised if FDA testing didn’t include different chiralities of both the original compound and metabolite.

That being said, there’s nothing to say one version of a chiral protein can’t behave like a prion. I don’t know of any evidence where we’ve seen it happen either, though. There’s also potentially the issue of partial bonding. Not every domain on every protein is chiral. If a mirror protein has some domains that bind but other functional domains that are incompatible, you could see it incorporated into complex that either 1) are now non-functional or 2) have alternate folding that behaves similar to prions.

Again though, I can’t point to any evidence of that. You can do the arrow pushing that shows how you get tetrodoxin from the stuff in your tea or coffee, it doesn’t mean it’s actually going to happen beyond the statistical realm interesting only to quantum physicists.

Just chiming in because your comments are level headed and you’ve clearly got some knowledge in the area and appreciate the discussion. Looking forward to digging into the report this weekend, I had no idea this was even something are even attempting!

Snow’s fantastic. You just make sure you have food and booze. Most (keyword most) employment is accommodating. Apart from that you make sure the heater vent is clear, if it’s a real fun one you might need to shovel the roof, but you prep to not go anywhere. OR the even MORE fun part is walking to the local bar.

That’s for relatively warm lake effect. That all goes out the window if it’s a truly brutal blizzard. Buffalo specifically had an ugly cold christmas a few years back that was absolutely brutal. People freezing to death leaving there cars looking for a house with someone home. Suspended emergency services. That was not the “fun” kind of snow storm.

I loved FC5. Ubisoft gets a lot of crap because they make the same game over and over but there’s a reason they started doing that. Good characters, and the pacing is pretty solid unless you’re a completions (which is your own fault). There’s some weird mechanics that progress the story that kind of break immersion that they chose because of the open world setting, but it’s a solid game. Enjoy!

If you like it, “new dawn” is pretty OK. Wait for it to be cheap, it’s basically really meaty DLC.

No joke: Uncle Sam was a real guy and Ive been to his grave. I forget if his wife was there (or if he had one).

No but it’s got a demo for free

People who don’t want to use the epic store. That was me. I just don’t want another launcher, another account. I’ll get around to it at some point I’m sure but I didn’t buy AW2 and probably would have if it wasn’t an exclusive.

No George Clinton was in parliament.

1. Yes: you absolutely want the outdoor rated PVC if you’re getting sun exposure. You can cheat, it’s not like the white stuff will be immediately destroyed, but if you want something that will last a bunch of seasons, the “grey” stuff is the way to go. Double check that it’s UV rated though, and doesn’t just happen to be grey.

2. To get around all of that, you can bury it. Because you’re just doing it for the garden, you don’t need to dig down to the frost line. Just make sure you clear the line at the end of the season. Another advantage is that you’ll minimize the amount of water that’s been baking in the sun idle in the pipes. If it’s a heatwave and they’re in direct sun, that water can get downright hot to the touch. I’ve never lost a plant because of it but frankly I’m kind of surprised by that. If you do bury, you might consider running some electrical conduit at the same time, even if you don’t put wires in it (DO however include a pull cable for later use). What you do at either end of that is a whole other project, but you can always just cap it and get it to it when you get to it. Solar + Battery usual works great for garden automation stuff, but being able to run an ethernet cable can simplify a lot.

3. Plastic will hold up fine, but as others have mentioned you might want one of these.. The union allows to remove it. You could do a more simple threaded system IF you are able to completely and freely rotate everything “down stream” of the valve. I’m just going to say the stupid part out loud because I learned pipe stuff the hard way: A ball valve threaded on both sides cannot be loosened from one side without tightening the other (again, unless that other side can freely rotate). Edit: alternatively unions are sold separately, and sometimes you can eek out some flow advantages that way but it’s in no way worth thinking about at garden water flow rates.

4. Finally, a last alternative I’ve seen done well for gardens that sort of “wrong done right” is putting posts up and stringing a hose over head. It kind of seemed like as much work/expense as burying it, but I guess they had the posts, it came out really sharp in the end. You need a pretty high quality hose though. Baking in the sun and sagging under the water weight can end badly.

My dad was a farmer. I AM AN ORPHAN.

Edit: Ok, I feel bad. But like… I know one dumbass with a cough that won’t go away (7 years and counting) because they wouldn’t effing listen to me about DE, another who rolled his tractor on to himself and died. Don’t take it lightly man. The bill always comes due. We all do what we have to, lord knows I’ve done some dumb shit, but it ain’t cute to dismiss it.

That and post-scarcity doesn’t mean “zero scarcity”. Like if someone wanted to create a picard funkpop the size of a planet, I don’t think they’d be allowed the resource budget.

It’s like how it doesn’t matter where you live, if you want to buy on the silk road, you need bitcoin. Presumably even the federation can’t just make latinum whenever they please, or we wouldn’t see them haggle with it. Although, it would be fun to see that they could and just take the responsibility of not crashing non-federation cultures entire economies very seriously, either out of respect or treaty.

Damnit, I want a LD episode where the crew is frustrated and desperately wants to just “buy” their problem away but can’t because an economist at command says it’ll mean they have to rescue all these non-federation colonies that are currently self sufficient. Come to think of it it’s right there with the “you break it you own it” concept of the prime directive.

Yeah like… Netflix has peering agreements and whatnot but… It’s not 2005.