Vitamin D3 is a good idea, generally the recommendation is 1000 IU a day. Especially now after the winter (assuming you’re in the Northern hemisphere) your vitamin D storage is probably depleted (the body needs a certain amount of UV radiation on the skin to produce vitamin D.

Regular exercise has been proven to help against depression and I think it’s probably the best and most important thing you can do. While helping your depression it will also help your general health and fitness.

Eat well: lots and lots of veggies, legumes and whole grain products. If unhealthy food makes you happy, don’t cut it from your diet completely. Allow yourself to eat sweets etc every once in a while and in moderation, but try to have a very healthy diet as a basis.

These things are probably hard to implement when you’re depressed in the first place but I guarantee you they’ll help and become easier as you go if you consistently stick to them. It takes about 66 days on average to build new habits. So if you manage to stick to it for about 2-3 months, it will become a lot easier.

Good luck!

Yes and no (and a disclaimer: I’m only a nurse). There are several herbs that work similarly to Selective Serotonin Reuptake Inhibitors (SSRIs). The issue being that they therefore have the same risks as SSRIs: the two big ones being serotonin syndrome (all your vital signs shoot up until it kills you) and less dangerously but not really less unpleasantly, mania and/or psychosis if that’s something your genetics have predisposed you do. These are both a lot less likely with herbs than medications because they’re much weaker, but it’s still possible, and especially if you take them WITH an SSRI. There are also some recreational drugs (shrooms, lsd, MDMA) that can cause serotonin syndrome when you take too much or take them with other serotonin boosting medications. I don’t recommend you play with this kind of thing without medical supervision. I actually had one of our severe bipolar cases come back to us high as tits because they swapped their mood stabilizer for a serotonergic herb, it was a mess.

Anyway the big three are St John’s Wort, Ashwaganda, and Moringa. L-tryptophan is also known to boost serotonin, but that’s just because it’s one of the building blocks your body needs to make it. Melatonin can also help your serotonin because it and serotonin turn into each other as part of the cycle of your circadian rhythm but be careful not to take too much of it because you’ll start having extremely bizarre nightmares.

But like I said, you’re better off talking to a doctor about this before you find out you’ve been bipolar II this entire time when the herbs you bought on Amazon turn it into bipolar I and you spend a month in a psych ward thinking your you’re the second coming of Christ and putting chess pieces in your ass to fight the demons.

Go on hikes through forested trails on a regular basis, no bullshit.

All the people saying exercise… I swear that has to vary across people. I went to the gym thrice a week for two years and hated every gd second of it.

Just mentioning this because I see all the others: spicy food. Your brain makes happy chemicals to help with the pain, apparently.

Exercise boosts endorphins.

Physical contact boosts oxytocin.

Sex does both.

Chocolate helps produce serotonin.

Capsaicin-heavy foods will make your body produce adrenaline and endorphins.

Caffeine is a drug but can give you a long hit of dopamine — but overdosing will make anxiety worse, and can fuck with your sleep cycle. It’s also rapidly addictive and the withdrawal symptoms include malaise and depressive feelings.

A stable sleep cycle is A#1 for happiness, though. It won’t make you happy on its own but screwing it up will make you unhappy on its own, so it’s the foundation to build everything else on.

Cats

Medicine won’t really help if you’re feeling depressed due to external factors. People who feel depressed because of their life situation typically benefit more from therapy both to learn how to cope more effectively and for guidance/support on making life changes. Look for sliding scales or low/no-cost therapy options in your area

Exercise, sauna, and completing small projects can help.

Vitamin D

A lot of people, especially those who don’t go outside, have a vitamin D deficiency. This is especially prevalent this time of year as winter is just ending.

A lot of depression symptoms can be tied to Vitamin D deficiency. Go out and get a supplement and take it for a week, see how you feel.

If your emotional distress is related to inflammation then even ibuprofen can give you some relief.

As for solutions outside of pills, exercise has always been the most effective thing for me in improving my happiness.

In terms of mental health, drugs that give any kind of relief should be treated as a shelter from the storm so you can rebuild. This means if you’re not rebuilding while you’re in shelter, your happiness is only going to last as long as your shelter is standing. Drugs wear off, and it is very easy to just want to keep putting your shelter up ad infinitum. This is where the second problem of drugs for relief comes in. The shelter is sub-standard compared to doing the things to build a lasting happiness. You can get stoned as shit, but if you and your life is still in shambles there’s only so much that can do.

All the above being said cannabis can help when you need a break. Psychedelics can help as well and microdosing incurs minimal risk. Neither of these will fix any of your problems, but they can enable you to work on your problems yourself when it was too difficult to before.

Alternatively, if you want to avoid drugs altogether meditation can be an option in some circumstances. This is barely a recommendation because meditation is a skill that you have to practice in optimal form consistently before you’ll get anything at all from it. It’s impossible to actually know whether you’re doing it right until you start to feel relief from it and so many things can make practicing mediation as a beginner almost impossible if you’re in crisis. If you attempt mediation with absolutely no expectations other than that you will fail at it until you happen to approach it in a way that works you may eventually get some relief from it. If you get it working consistently, it is far stronger than anything you can get legally without a prescription in terms of providing relief. I can give you some guidance if you’re interested in this path. Secondarily, Kava can help a little in that it dulls the pain.

Vallerian root, kanna, ashwaganda, etc. might work if you believe strongly that they’re working. Avoid depressants like alcohol because although they provide temporary relief they also make things worse when they wear off which can be a terrible cycle.

The line between medicine and drug is largely arbitrary.

Start with the basics of diet, exercise, water, sleep, social interaction. They’re consistent and have very low harm potential. It’s also shocking how much each of them contributed to a sense of well being, or how much a lack of any one of them can cause a downward spiral.

Supplements and vitamins also aren’t super risky, although they aren’t well regulated and many do nothing in their pill form. One or some of the vitamin Bs seem important for me personally, although I’m not 100% certain and I don’t know which one(s) and to what degree. But I’ll drink a monster energy regularly because they have 200-400% dv. Omegas from fish oils may also be good. L-tyrosine and things like it are commonly discussed in nootropics boards, I can’t vouch for them personally.

As far as medications, it’s unlikely you’ll find an easy and risk-free solution, unfortunately. Even well-studied prescription medications aren’t guaranteed to work for your specific needs and have potential to make things worse, which is why in an ideal world everyone would have access to a medical professional that can oversee their use. And often the ones that work aren’t immediately obvious, but demonstrate marginal improvement over the longer term. In fact euphoria and hypomania (which in the moment feel like “oh my god this drug is working”) may be signs the drug isn’t a good fit. Very difficult to gauge on your own.

Online prescription mills are fairly painless if you have a good idea that a specific medication might work for you. I used them to get on a specific antidepressant after doing my own research.

Kanna and St John’s wort both have SSRI compounds I believe. Be careful, just because something’s a legal plant doesn’t mean it can’t interact negatively or have harmful effects. But these are probably the closest to what you’re asking.

Kratom is legal and can boost mood but has high addictive potential. In my experience not worth it except to get off more addictive substances.

Dex/dxm/dextromethorphan is an active ingredient in some cough suppressants that has antidepressive potential. Can be purchased with no additives at some pharmacies and online. Tripping on this isn’t fun at all in my opinion, I’d rather do salvia, but small doses seem to have some mood improving effects that last a few days

Stay away from diphenhydramine (I mention it because it’s often spoken of in the same context as Dex). Its use has been linked to dementia.

Psychedelics can help deconstruct old assumptions and mental structures that may be contributing to your depression. I’d describe the experience as rediscovering the magic of existence. Many of them also have antidepressant qualities-- a sort of afterglow that may last a week or a month. Microdosing is said to tap into the afterglow without tripping. LSD and shrooms are fairly well-studied. Mescaline acts similarly and may be easier to find. Morning glory seeds are legal and contain LSA which is similar to LSD. Salvia acts differently than any of these, often leading to bad trips, but is generally legal. None of these are addictive, but may be risky for people with certain mental illnesses.

There are a variety of legal and grey market stims that can improve mood, but they may have harmful effects and addictive potential. You’ll find a bunch of them if you browse nootropics boards, but keep in mind anonymous comments are not scientific and may undersell risk and negative effects. Nootropics boards will also discuss other supposedly cognitive enhancing substances. Lions mane is a common one. Some are natural supplements or things your body already produces (though this doesn’t guarantee they’re safe or pure). Many are addictive, many are probably snake oil. Search a drug/supplement on pubmed before trying it.

Adjacent to nootropics and more dangerous is research chemicals. Half of them are attempts to make “legal” but identical/similar analogues to illegal drugs. Some are novel. Almost none of them have been studied and purity is never guaranteed. I Honestly don’t recommend unless you’re at a point where it doesn’t matter. At one point for me it was “find a happy chemical or commit suicide” and I think that’s the only level this kind of experimentation is truly justified. But well-studied psychedelics are preferable.

St Johns Wort can help. It’s not as effective as prescription medication, but can help deal with mild ‘low mood’ type symptoms. It’s comparable to the effect of a compression bandage on a joint. It will help with the equivalent of a pulled tendon, but will do next to nothing against the equivalent of a shattered elbow.

It is worth noting that there are 2 sorts of depression. Feeling sad, while unpleasant, is a lot easier to treat. It’s generally caused by external stimulus. While this is harder to treat with drugs, it responds a LOT better to lifestyle changes. Basically, you need to figure out 2 things. What is making you sad, and how do you remove that effect. Implementing it can be an absolute bitch, but it’s worth the effort.

The other sort of depression is proper “clinical depression”. This is a chemical imbalance in the brain. It can be brought on by external stimulus, but it’s not dependent on them. With this, your brain starts losing the ability to care. Motivation becomes a lot harder, and so the cost to payoff with positive activities gets worse. Internally, it’s like having the chroma on a TV turned down. Everything gets muted and dull. Nothing is worth the effort required to do it. This sort of depression does need proper treatment. It’s far more insidious and will grind you down. To beat it you need to change your very brain wiring. This can be done, but generally requires significant external support. If you could beat it alone, you likely wouldn’t have become trapped within it.

I’ve experienced both. Neither are pleasant. Just keep in mind, both distort your thinking. Often, you can’t fully trust your own thinking. Situations that seem impossible to cope with will just crumble when actually attacked. However, without enough motivation, you often won’t even try.

An just to note, if you get to the point of intrusive, self destructive thoughts, that’s when you need to seriously reach out to external help. Even if you think you can cope with them, they can send your mind spiraling downwards.

5-HTP is a mood-regulating supplement, like a mild anti-depressant. I once took it for a year and it actually helped. But for the first week it made me more emotional. Read about it on webMD so you understand it and the risks.

But the real answer is exercise, healthy diet, and maybe vitamin D. Boring answer, I know, but the absolute best one too.